abstract：UNLABELLED:Study Type--Therapy (practise pattern survey) Level of Evidence 3b. What's known on the subject? and What does the study add? Congenital penile deviation has become a relatively frequent finding due to a greater awareness of the problem among patients and physicians. Since the first surgical correction for c...

journal_title：BJU international

authors： Kuehhas FE,Egydio PH

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Upper Urinary Tract (UUT) Transitional Cell Carcinoma (TCC) is an uncommon disease and represents approximately 5% of all urothelial carcinomas. We report our series on 73 patients treated with Kidney Sparing Surgery for UUT TCC. Good results have bee...

journal_title：BJU international

authors： Simonato A,Varca V,Gregori A,Benelli A,Ennas M,Lissiani A,Gacci M,De Stefani S,Rosso M,Benvenuto S,Siena G,Belgrano E,Gaboardi F,Carini M,Bianchi G,Carmignani G

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? The common clinical practice for advanced prostatic adenocarcinoma is combination therapy of zoledronic acid (ZA) and docetaxel (TAX). Little is known about the consequences of this combination therapy with regard to osteonecrosis of the jaw (ONJ). Th...

journal_title：BJU international

authors： Miyazaki H,Nishimatsu H,Kume H,Suzuki M,Fujimura T,Fukuhara H,Enomoto Y,Ishikawa A,Igawa Y,Hirano Y,Homma Y

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Despite expanding treatment options for castration-resistant prostate cancer (CRPC), therapies with long response duration remain intangible due to prostate cancer cells' natural ability to develop it...

journal_title：BJU international

authors： Nakabayashi M,Werner L,Courtney KD,Buckle G,Oh WK,Bubley GJ,Hayes JH,Weckstein D,Elfiky A,Sims DM,Kantoff PW,Taplin ME

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Recent studies have indicated that high mobility group box 1 (HMGB1) is related to the development and progression of human carcinomas. However, further studies were required to confirm the roles played by HMGB1 in clinical prostate cancer treatment. ...

journal_title：BJU international

authors： Li T,Gui Y,Yuan T,Liao G,Bian C,Jiang Q,Huang S,Liu B,Wu D

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? There have been few studies evaluating the prognostic value of epithelial-mesenchymal transition markers in renal cell carcinoma (RCC); therefore, the significance of these markers in the prognosis of patients with RCC, particularly that in those with...

journal_title：BJU international

authors： Harada K,Miyake H,Kusuda Y,Fujisawa M

更新日期：2012-12-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incid...

journal_title：BJU international

authors： Stock RG,Berkowitz J,Blacksburg SR,Stone NN

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To determine, in a population-based cohort, if disease-specific survival (DSS) was equivalent in patients undergoing ablation vs nephron-sparing surgery (NSS) for clinical stage T1a renal cell carcinoma (RCC). PATIENTS AND METHODS:A retrospective cohort study was performed using patients from the Surveillanc...

journal_title：BJU international

authors： Whitson JM,Harris CR,Meng MV

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...

journal_title：BJU international

authors： Moskovic DJ,Katz DJ,Akhavan A,Park K,Mulhall JP

更新日期：2012-11-01 00:00:00

abstract：:What's known on the subject? and What does the study add? With recent improvements in the prognosis for patients with metastatic renal cell carcinoma (mRCC), focus is now shifting towards maximising clinical benefit from targeted therapies. Factors other than efficacy data are increasingly being considered when select...

journal_title：BJU international

authors： Bex A,Gore M,Mulders P,Sternberg CN

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...

journal_title：BJU international

authors： Aydin M,Wang HZ,Zhang X,Chua R,Downing K,Melman A,DiSanto ME

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:To explore the role of transient receptor potential vanilloid 1 (TRPV1) in the excitatory effects of chronic administration of nerve growth factor (NGF) on bladder-generated sensory input and reflex activity. To explore new therapeutic targets for bladder dysfunction. MATERIALS AND METHODS:Wild-type (WT) an...

journal_title：BJU international

authors： Frias B,Charrua A,Avelino A,Michel MC,Cruz F,Cruz CD

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? In the 1980s and 1990s, a method for direct measurement of pressure and cross-sectional area in women and men was developed. It was successful in terms of obtaining meaningful results in several studies. But the technique, which was based on the field...

journal_title：BJU international

authors： Aagaard M,Klarskov N,Sønksen J,Bagi P,Colstrup H,Lose G

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a sho...

journal_title：BJU international

authors： Pereira-Correia JA,de Moraes Sousa KD,Santos JB,de Morais Perpétuo D,Lopes-da-Silva LF,Krambeck RL,Muller VJ,Vaz FP

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? To date, there has been limited impetus to examine the use of cytarabine in prostate cancer. We presented preliminary laboratory data to suggest its utility in the castration refractory prostate cancer (CRPC) population which, combined with a previous...

journal_title：BJU international

authors： Dhani NC,Emmenegger U,Adams L,Jongstra J,Tannock IF,Sridhar SS,Knox JJ,Day JR,Groskopf J,Joshua AM

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...

journal_title：BJU international

authors： Fariello RM,Pariz JR,Spaine DM,Cedenho AP,Bertolla RP,Fraietta R

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...

journal_title：BJU international

authors： Ohmasa F,Saito M,Oiwa H,Tsounapi P,Shomori K,Kitatani K,Dimitriadis F,Kinoshita Y,Satoh K

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? L-dopa decarboxylase (DDC) has been documented as a novel co-activator of androgen receptor transcriptional activity. Recently, it was shown that DDC gene expression is significantly higher in patients with PCa than in those with BPH. In the present s...

journal_title：BJU international

authors： Koutalellis G,Stravodimos K,Avgeris M,Mavridis K,Scorilas A,Lazaris A,Constantinides C

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical prostatectomy are common, although their impact on the risk of disease recurrence is unknown. We examined the impact of PSMs on the risk of 'significant' biochemical recurrence stratified by their risk of...

journal_title：BJU international

authors： Corcoran NM,Hovens CM,Metcalfe C,Hong MK,Pedersen J,Casey RG,Peters J,Harewood L,Goldenberg SL,Costello AJ,Gleave ME

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJEC...

journal_title：BJU international

authors： Shokeir AA,Hussein AA,Soliman SA,Kamal MM,Abdel-Aziz A,Awadalla A,Rahim MA,Barakat N

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Sunitinib and sorafenib are orally administered multikinase inhibitors approved for the treatment of advanced RCC. The limited pharmacokinetics data on sunitinib and sorafenib suggest that haemodialysis does not significantly alter plasma concentratio...

journal_title：BJU international

authors： Masini C,Sabbatini R,Porta C,Procopio G,Di Lorenzo G,Onofri A,Buti S,Iacovelli R,Invernizzi R,Moscetti L,Aste MG,Pagano M,Grosso F,Lucia Manenti A,Ortega C,Cosmai L,Del Giovane C,Conte PF

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:• To conduct a case-control study evaluating clinical symptom severity and sexual dysfunction in women with ketamine cystitis (KC). PATIENTS AND METHODS:• In total, 29 patients with KC and 27 controls completed the symptoms survey. • Participants completed a visual pelvic pain analogue scale, an O'Leary-Sant...

journal_title：BJU international

authors： Jang MY,Long CY,Chuang SM,Huang CH,Lin HY,Wu WJ,Juan YS

更新日期：2012-08-01 00:00:00

abstract：UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...

journal_title：BJU international

authors： Ruf CG,Linbecker M,Port M,Riecke A,Schmelz HU,Wagner W,Meineke V,Abend M

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...

journal_title：BJU international

authors： Mazzola CR,Deveci S,Heck M,Mulhall JP

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The widespread use of serum PSA testing followed by TRUS-guided biopsy have resulted in profound prostate cancer stage migration with many patients presenting with focal rather than mul...

journal_title：BJU international

authors： Washington SL,Bonham M,Whitson JM,Cowan JE,Carroll PR

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? Protein kinase C inhibitor (PKCI) can decrease glomerular and tubular cell apoptosis and mitosis and attenuate collagen accumulation and fibronectin expression in a PUUO rat model. Although the role of PKC has been well studied in diabetic nephropathy...

journal_title：BJU international

authors： Juan YS,Chuang SM,Long CY,Lin RJ,Liu KM,Wu WJ,Huang CH

更新日期：2012-07-01 00:00:00

abstract：UNLABELLED:What's known on the subject? and What does the study add? For the past 30 years Serenoa repens has become a widely used phytotherapy in the USA and in Europe, mostly because of positive comparisons to α-blockers and 5α-reductase inhibitors. During the last 4 years we have seen two very high quality trials co...

journal_title：BJU international

authors： MacDonald R,Tacklind JW,Rutks I,Wilt TJ

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Selective destruction of targeted prostate tissue is now technically feasible. Much has been theorized but little is known about the proper patient selection or treatment outcomes to determine if this...

journal_title：BJU international

authors： Ward JF,Jones JS

更新日期：2012-06-01 00:00:00

abstract：:What's known on the subject? and What does the study add? The suppressor effect of probiotics on superficial bladder cancer is an observed phenomenon but the specific mechanism is poorly understood. The evidence strongly suggests natural killer (NK) cells are the anti-tumour effector cells involved and NK cell activit...

journal_title：BJU international

authors： Feyisetan O,Tracey C,Hellawell GO

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The present study was to perform contrast-tuned imaging (CnTI) technology to detect prostate cancer and compare the use of CnTI technology for the detection of prostate cancer with conv...

journal_title：BJU international

authors： Xie SW,Li HL,Du J,Xia JG,Guo YF,Xin M,Li FH

更新日期：2012-06-01 00:00:00

abstract：:Since Huggins and Hodges demonstrated the responsiveness of prostate cancer to androgen deprivation therapy (ADT), androgen-suppressing strategies have formed the cornerstone of management of advanced prostate cancer. Approaches to ADT have included orchidectomy, oestrogens, luteinizing hormone-releasing hormone (LHRH...

journal_title：BJU international

authors： Schröder F,Crawford ED,Axcrona K,Payne H,Keane TE

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Study Type--Therapy (case series). Level of Evidence 4. What's known on the subject? And what does the study add? Adverse outcomes after radical prostatectomy are more often recorded in the elderly. In the USA, elderly patients undergoing radical prostatectomy are treated at institutions where suboptimal out...

journal_title：BJU international

authors： Trinh QD,Schmitges J,Sun M,Shariat SF,Sukumar S,Tian Z,Bianchi M,Sammon J,Perrotte P,Rogers CG,Graefen M,Peabody JO,Menon M,Karakiewicz PI

更新日期：2012-05-01 00:00:00

abstract：UNLABELLED:Study Type - Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does the study add? Men with prostate cancer have higher rates of non-cancer mortality and CV morbidity and some of that excess risk has been attributed to the treatment they receive. ADT is an established treatment option ...

journal_title：BJU international

authors： Nobes JP,Langley SE,Klopper T,Russell-Jones D,Laing RW

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...

journal_title：BJU international

authors： Lu L,Peters J,Roome C,Stein K

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To report the incidence, risk factors, and outcomes of subcapsular renal haematoma (SRH) after ureteroscopic lithotripsy (URSL) using holmium:yttrium-aluminum-garnet (Ho:YAG) laser to treat ureteric stones. PATIENTS AND METHODS:Prospective data from 2848 URSLs performed between January 2003 and September 201...

journal_title：BJU international

authors： Bai J,Li C,Wang S,Liu J,Ye Z,Yu X,Xi Q,Ni M,He D

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention. MATERIALS AND METHODS:The effi...

journal_title：BJU international

authors： Chen SC,Grill WM,Fan WJ,Kou YR,Lin YS,Lai CH,Peng CW

更新日期：2012-04-01 00:00:00

abstract：:Detrusor sphincter dyssynergia (DSD) is variant of neurogenic bladder dysfunction caused by suprasacral neurological abnormalities and may be associated with serious complications if unrecognised. This paper focuses on the clinical features as well as challenges and limitations in the diagnosis of DSD. ...

journal_title：BJU international

authors： Bacsu CD,Chan L,Tse V

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:• To employ decision curve analysis to determine the impact of nuclear matrix protein 22 (NMP22) on clinical decision making in the detection of bladder cancer using data from a prospective trial. PATIENTS AND METHODS:• The study included 1303 patients at risk for bladder cancer who underwent cystoscopy, uri...

journal_title：BJU international

authors： Barbieri CE,Cha EK,Chromecki TF,Dunning A,Lotan Y,Svatek RS,Scherr DS,Karakiewicz PI,Sun M,Mazumdar M,Shariat SF

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:• To evaluate the effect of transurethral resection of the prostate (TURP) on sexual function in the short (6 months), medium (6 years) and long (12 years) term and assess the conformity between patient and partner regarding sexual function. PATIENTS AND METHODS:• A prospective cohort study set at the Aberde...

journal_title：BJU international

authors： Mishriki SF,Grimsley SJ,Lam T,Nabi G,Cohen NP

更新日期：2012-03-01 00:00:00

abstract：:Interactive case studies formed a key feature of the third annual Interactive Genitourinary Cancer Conference held in April/May 2011 in Budapest, Hungary. These cases were used to discuss the practical aspects of the management of metastatic castration-resistant prostate cancer (mCRPC). Particular emphasis was placed ...

journal_title：BJU international

authors： Bahl A,Bellmunt J,Oudard S

更新日期：2012-03-01 00:00:00